Repeat resection for recurrent glioblastoma – does timing matter?

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Glioblastoma is characterized by poor prognosis, with a median overall survival of around 15 months despite multimodal therapy.
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Repeat resection for recurrent glioblastoma can improve median survival to 12-18 months, with a postoperative neurological deterioration rate of about 8%.
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Up to 40% of glioblastoma patients may experience pseudo-progression during treatment, complicating the assessment of treatment response.
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Management strategies for recurrent glioblastoma vary, including upfront repeat resection, watch-and-wait, or salvage therapy, leading to heterogeneous outcomes.
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The study aims to evaluate the risks and outcomes associated with early versus late repeat resection for recurrent glioblastoma.

Journal Of Neuro-Oncology

by Obada T. Alhalabi, Kirill Mironov, Khurshed Nabiev, Johanna Krämer, Nour Gareib, Henri Olldashi, Stefan Joser, Marianne Schell, Sandro M. Krieg, Andreas W. Unterberg, Christine Jungk
February 24, 2026

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