Spatial transcriptomics reveals molecular differences associated with malignant transformation in oral epithelial dysplasia - Takeaways - MDSpire

Spatial transcriptomics reveals molecular differences associated with malignant transformation in oral epithelial dysplasia

  • By

  • Naren Raja

  • Harsh B. Pathak

  • Amrita Mitra

  • Sufi Mary Thomas

  • Yong Wang

  • Tanya Marie Gibson

  • Rong Wang

  • July 10, 2026

  • 0 min

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  • 1

    The study utilized spatial transcriptomics to analyze benign, oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) biopsies.

  • 2

    A total of 42 archived oral biopsy samples were analyzed, including 13 benign, 15 OED (8 transforming, 7 non-transforming), and 14 OSCC.

  • 3

    Eleven differentially expressed genes were identified in transforming versus non-transforming OED, linked to antigen presentation and interferon signaling.

  • 4

    Pathway analyses revealed enrichment of immune- and interferon-related processes in transforming OED lesions.

  • 5

    The findings suggest altered epithelial-immune interactions in transforming lesions, warranting further validation in future studies.

Original Source(s)

Spatial transcriptomics reveals molecular differences associated with malignant transformation in oral epithelial dysplasia

  • by Naren Raja, Harsh B. Pathak, Amrita Mitra, Sufi Mary Thomas, Yong Wang, Tanya Marie Gibson, Rong Wang

  • July 10, 2026

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