Identification of immunosuppressive neutrophils using multi-omics: why functional testing remains key - Takeaways - MDSpire

Identification of immunosuppressive neutrophils using multi-omics: why functional testing remains key

  • By

  • Fleur van Oosterom

  • Angela A. F. Gankema

  • Felipe Rojas-Rodriguez

  • Arie J. Hoogendijk

  • Taco W. Kuijpers

  • May 18, 2026

  • 0 min

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  • 1

    Polymorphonuclear neutrophils (PMNs) can act as myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment.

  • 2

    Single-cell RNA sequencing (scRNAseq) has advanced the study of neutrophil subsets, but clear immunophenotypic characterization of PMN-MDSCs remains elusive.

  • 3

    Neutrophils play a dual role in cancer, contributing to both anti-tumor immunity and tumor progression through immunosuppressive mechanisms.

  • 4

    Low-density neutrophils (LDNs) exhibit immunosuppressive capacity, accumulating with cancer progression, while normal density neutrophils (NDNs) also show similar traits.

  • 5

    Further development of single-cell techniques, including proteomics, is essential for defining functional neutrophil subsets and understanding their plasticity.

Original Source(s)

Identification of immunosuppressive neutrophils using multi-omics: why functional testing remains key

  • by Fleur van Oosterom, Angela A. F. Gankema, Felipe Rojas-Rodriguez, Arie J. Hoogendijk, Taco W. Kuijpers

  • May 18, 2026

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