Repurposing loratadine to induce ferroptosis and overcome multidrug resistance: preclinical evidence in KB-V-1 cells - Takeaways - MDSpire

Repurposing loratadine to induce ferroptosis and overcome multidrug resistance: preclinical evidence in KB-V-1 cells

  • By

  • Nicholas Cook

  • Xin Li

  • Nathan J. Bowen

  • Alira Danaher

  • MaKayla Thomas

  • Saani Alhassan

  • Briah Arms

  • Daqing Wu

  • June 17, 2026

  • 0 min

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  • 1

    Loratadine induces ferroptosis in MDR1-overexpressing KB-V-1 cells, overcoming multidrug resistance in cancer treatment.

  • 2

    The study confirmed ferroptosis as the primary mechanism of cell death induced by loratadine through various assays.

  • 3

    Loratadine selectively inhibited the viability of KB-V-1 cells while sparing chemosensitive KB-3–1 cells.

  • 4

    In vivo, loratadine reduced tumor growth and enhanced the efficacy of paclitaxel without causing systemic toxicity.

  • 5

    These findings support loratadine as a promising candidate for repurposing in ferroptosis-based cancer therapies.

Original Source(s)

Repurposing loratadine to induce ferroptosis and overcome multidrug resistance: preclinical evidence in KB-V-1 cells

  • by Nicholas Cook, Xin Li, Nathan J. Bowen, Alira Danaher, MaKayla Thomas, Saani Alhassan, Briah Arms, Daqing Wu

  • June 17, 2026

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