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Sertoli Cell Tumor Associated with Familial Adenomatous Polyposis: A Case Study

  • By

  • Chandra Kakarala

  • Katie Bussing

  • Reema Patel

  • Jessica Moss

  • Zin W. Myint

  • August 24, 2026

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  • 1

    A 50-year-old man with familial adenomatous polyposis (FAP) and colonic adenocarcinoma was found to have a Sertoli cell tumor during evaluation.

  • 2

    Histopathologic assessment revealed a Sertoli cell tumor lacking high-risk features, with diffuse nuclear beta-catenin expression.

  • 3

    The patient had a heterozygous pathogenic APC mutation, suggesting a potential link between APC mutations and Sertoli cell tumors.

  • 4

    Testicular neoplasms are rare, constituting 1-2% of male neoplasms, with Sertoli cell tumors accounting for about 1% of all testicular tumors.

  • 5

    The patient underwent adjuvant chemotherapy and subsequent treatments for rectal adenocarcinoma, with no evidence of disease progression noted.

Original Source(s)

Sertoli cell tumor in familial adenomatous polyposis: a case report

  • by Chandra Kakarala, Katie Bussing, Reema Patel, Jessica Moss, Zin W. Myint

  • August 24, 2026

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