Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin - Takeaways - MDSpire

Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin

  • By

  • Jayastu Senapati

  • Elias Jabbour

  • Nicholas J. Short

  • Nitin Jain

  • Fadi Haddad

  • Tharakeswara Bathala

  • Iuliia Kovalenko

  • Aram Bidikian

  • Farhad Ravandi

  • Issa Khouri

  • Tapan M. Kadia

  • Rebecca Garris

  • Guillermo Montalban Bravo

  • Kelly Chien

  • Elizabeth Shpall

  • Partow Kebriaei

  • Hagop M. Kantarjian

  • August 7, 2024

  • 0 min

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  • 1

    Inotuzumab ozogamicin (InO) significantly improves outcomes in B-cell acute lymphoblastic leukemia but is associated with hepatic toxicity.

  • 2

    The rate of sinusoidal obstruction syndrome (SOS) was 14% in the InO arm compared to 2% in the standard of care arm in the INO-VATE trial.

  • 3

    Liver elastography is a non-invasive method that can detect liver toxicity and SOS in patients receiving InO for B-cell ALL.

  • 4

    In a study, 78% of patients had normal liver stiffness measurements, and only 2% developed SOS after treatment with InO.

  • 5

    Factors such as age, prior liver disease, and cumulative InO dosage are associated with increased risk of SOS in patients undergoing HSCT.

Original Source(s)

Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin

  • by Jayastu Senapati, Elias Jabbour, Nicholas J. Short, Nitin Jain, Fadi Haddad, Tharakeswara Bathala, Iuliia Kovalenko, Aram Bidikian, Farhad Ravandi, Issa Khouri, Tapan M. Kadia, Rebecca Garris, Guillermo Montalban Bravo, Kelly Chien, Elizabeth Shpall, Partow Kebriaei, Hagop M. Kantarjian

  • August 7, 2024

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