Reevaluation of the Immune Profile in Scalp Psoriasis: A Cross-Sectional Analysis Utilizing Olink Proteomics

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The study analyzed 92 inflammatory biomarkers in scalp psoriasis patients using Olink high-throughput proteomics.
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Twenty-eight differentially expressed proteins were identified in lesional scalp skin of psoriasis patients compared to healthy controls.
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Scalp psoriasis exhibited a Th1/Th17/IL-12/IL-23-dominant molecular signature with down-regulation of Th2-type cytokines.
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Reduced levels of IL-4 and IL-5 in scalp psoriasis were negatively correlated with scalp-specific Investigator’s Global Assessment scores.
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The findings suggest an imbalance between Th2 and Th1/Th17/IL-12/IL-23 responses in the immunological pathogenesis of scalp psoriasis.

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