Determinants Influencing the Administration of Adjuvant Radiation Therapy in Patients with Locally Advanced Rectal Cancer

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Radiotherapy has been a key treatment for rectal cancer, evolving from adjuvant to neoadjuvant approaches based on clinical trial findings.
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Adjuvant chemoradiation is primarily reported for incidental nodal disease or pathologic upstaging after surgery for early-stage tumors.
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The study analyzed factors associated with adjuvant RT use for locally advanced rectal cancer using data from the National Cancer Database.
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A total of 48,452 patients with locally advanced rectal cancer were analyzed, with 93.1% receiving neoadjuvant RT and 6.9% receiving adjuvant RT.
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The study aimed to identify sociodemographic determinants contributing to disparities in adjuvant RT administration among rectal cancer patients.

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