HEK293 Cell Line for rAAV Manufacturing

New study reports two-fold improvement in full-to-empty rAAV ratio versus commercial HEK293 line

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NewBiologix developed the NBX1P01 clonal HEK293 cell line for enhanced recombinant adeno-associated virus (rAAV) production.
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NBX1P01 achieved a two-fold higher full-to-empty rAAV capsid ratio compared to a leading commercial HEK293 cell line.
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The cell line demonstrated genomic stability over 55 population doublings with lower genetic heterogeneity than parental HEK293.
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Long-read sequencing confirmed over 70% intact rAAV genomes with minimal encapsidated contaminating DNA.
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NBX1P01 supports scalable production from 10 mL to 1.5 L and is versatile for multiple rAAV serotypes and transgene sizes.