Liver involvement in pediatric acute leukemia: subtype differences and complex hepatic injury as a novel marker for AML risk stratification - Takeaways - MDSpire

Liver involvement in pediatric acute leukemia: subtype differences and complex hepatic injury as a novel marker for AML risk stratification

  • By

  • Yu-juan Xue

  • Yu Wang

  • Ai-dong Lu

  • Yue-ping Jia

  • Zhi-xiao Zhang

  • Lin Zhang

  • Xiaoyu Cao

  • Le-ping Zhang

  • Hui-min Zeng

  • May 7, 2026

  • 0 min

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  • 1

    Liver involvement in pediatric acute leukemia varies by subtype, with T-ALL showing the highest prevalence at 80%.

  • 2

    Hepatomegaly was the most common manifestation of liver involvement across all leukemia subtypes.

  • 3

    Complex hepatic injury in AML patients correlates with poorer overall and event-free survival outcomes.

  • 4

    Lower platelet counts are significantly associated with hepatomegaly and hepatocellular injury in pre-B-ALL.

  • 5

    Age and white blood cell counts are important factors associated with liver involvement in pediatric acute leukemia.

Original Source(s)

Liver involvement in pediatric acute leukemia: subtype differences and complex hepatic injury as a novel marker for AML risk stratification

  • by Yu-juan Xue, Yu Wang, Ai-dong Lu, Yue-ping Jia, Zhi-xiao Zhang, Lin Zhang, Xiaoyu Cao, Le-ping Zhang, Hui-min Zeng

  • May 7, 2026

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