Durable disease control after multimodal therapy and platinum-based chemotherapy rechallenge in advanced clear cell adenocarcinoma of the urethra with lymph node metastases: a case report - Takeaways - MDSpire

Durable disease control after multimodal therapy and platinum-based chemotherapy rechallenge in advanced clear cell adenocarcinoma of the urethra with lymph node metastases: a case report

  • By

  • Akihiro Maeda

  • Shohei Tobu

  • Shuhei Kusano

  • Maki Kawasaki

  • Hiroaki Kakinoki

  • Mitsuru Noguchi

  • June 22, 2026

  • 0 min

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  • 1

    Clear cell adenocarcinoma of the urethra (CCAU) is a rare malignancy with unclear optimal treatment strategies for advanced disease.

  • 2

    A 60-year-old woman with advanced CCAU achieved long-term disease control following multimodal treatment, including chemotherapy and radical surgery.

  • 3

    Neoadjuvant gemcitabine plus cisplatin chemotherapy resulted in a partial response, leading to subsequent radical cystourethrectomy.

  • 4

    Postoperative treatment with nivolumab was discontinued due to immune-related hypothyroidism and nodal recurrence.

  • 5

    Reintroduction of gemcitabine and cisplatin chemotherapy after recurrence achieved another partial response, with the patient progression-free for 32 months.

Original Source(s)

Durable disease control after multimodal therapy and platinum-based chemotherapy rechallenge in advanced clear cell adenocarcinoma of the urethra with lymph node metastases: a case report

  • by Akihiro Maeda, Shohei Tobu, Shuhei Kusano, Maki Kawasaki, Hiroaki Kakinoki, Mitsuru Noguchi

  • June 22, 2026

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