RNA binding protein YWHAZ mediates specific mRNA translation and regulates cell proliferation and apoptosis in diabetic foot ulcer

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YWHAZ is significantly upregulated in diabetic foot ulcer (DFU) tissues, indicating its potential role in the condition's pathology.
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Knockdown of YWHAZ in HaCaT cells enhances proliferation and migration while reducing apoptosis, suggesting its regulatory influence.
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RNA-seq analysis identified 1,072 differentially expressed genes in YWHAZ knockdown cells, linked to cell proliferation and adhesion.
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YWHAZ associates with numerous mRNAs, particularly binding to GC-rich motifs, influencing gene expression in DFU.
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The study highlights YWHAZ's potential as a therapeutic target for improving healing processes in diabetic foot ulcers.

Frontiers In Medicine

by Tianjian Zha, Junjie Yao, Hao Wang, Qiang Cao, Jian Zhang, Zhao Chen, Jie Wang
May 7, 2026

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