Infants show improving survival after hematopoietic cell transplantation despite high rates of critical care admission - Takeaways - MDSpire

Infants show improving survival after hematopoietic cell transplantation despite high rates of critical care admission

  • By

  • Shaikha Alqahtani

  • Fabiana Cacace

  • Beiyu Liu

  • Hwanhee Hong

  • Erika Summers

  • Lauren Stafford

  • Brittany Paige DePriest

  • Carmem Bonfim

  • Timothy A. Driscoll

  • Jennifer Jaroscak

  • Shatha Yousef

  • Joanne Kurtzberg

  • Kris M. Mahadeo

  • July 14, 2026

Share

  • 1

    Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for infants with non-malignant inherited disorders and high-risk hematologic malignancies.

  • 2

    In this study, 107 infants underwent HCT, with a median age of 5.81 months, primarily for non-malignant indications (90.7%).

  • 3

    Within 100 days post-HCT, 41% of infants required critical care support, mainly due to respiratory distress.

  • 4

    Overall survival rates were 85.9% at 100 days and 73.5% at 1 year post-HCT, with improved outcomes for those transplanted after 2013.

  • 5

    Infants requiring critical care support had a significantly higher risk of mortality compared to those who did not require such support.

Original Source(s)

Infants show improving survival after hematopoietic cell transplantation despite high rates of critical care admission

  • by Shaikha Alqahtani, Fabiana Cacace, Beiyu Liu, Hwanhee Hong, Erika Summers, Lauren Stafford, Brittany Paige DePriest, Carmem Bonfim, Timothy A. Driscoll, Jennifer Jaroscak, Shatha Yousef, Joanne Kurtzberg, Kris M. Mahadeo

  • July 14, 2026

Related Content

Bivalirudin as rescue therapy for suspected heparin resistance and recurrent intra-procedural stent thrombosis during complex percutaneous coronary intervention: a case report

Pharmacokinetic-guided versus weight-guided coagulation factor replacement in hemophilia patients undergoing arthroplasty: a retrospective real-world study on perioperative bleeding risk and economic outcomes

Evaluation of pre-dilution combined with optical/fluorescent platelet counting for correcting pseudothrombocytopenia