Case Report: Efgartigimod: a beacon of hope for overlapping stiff-person syndrome and myasthenia gravis following thymoma - Takeaways - MDSpire

Clinical Case Study: Efgartigimod as a Promising Treatment for Concurrent Stiff-Person Syndrome and Myasthenia Gravis Associated with Thymoma

  • By

  • Jingjing Nie

  • Weifan Yin

  • July 20, 2026

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  • 1

    Stiff person syndrome (SPS) and myasthenia gravis (MG) coexistence is rare, with fewer than 20 cases reported, often associated with thymoma.

  • 2

    A 43-year-old woman diagnosed with SPS developed anti-acetylcholine receptor antibody-positive MG four years later, linked to type B2 thymoma.

  • 3

    Conventional treatments for MG, including plasma exchange and corticosteroids, failed to improve the patient's condition after thymectomy.

  • 4

    Efgartigimod treatment resulted in significant recovery of respiratory and motor function in the patient with refractory thymoma-associated MG.

  • 5

    Long-term monitoring for thymoma and additional autoimmune disorders is recommended for patients with SPS due to potential overlapping conditions.

Original Source(s)

Case Report: Efgartigimod: a beacon of hope for overlapping stiff-person syndrome and myasthenia gravis following thymoma

  • by Jingjing Nie, Weifan Yin

  • July 20, 2026

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