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1
This study systematically analyzed the efficacy of traditional Chinese medicine (TCM) in treating neonatal pneumonia (NP) through meta-analysis and experimental assessment.
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2
A meta-analysis identified a TCM bath formula with significant clinical efficacy, composed of Perilla frutescens, Radix Bupleuri, Mentha haplocalyx, and Schizonepeta tenuifolia.
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3
Naringenin was identified as a key active component, showing strong binding affinity to MAPK1, which plays a role in inflammatory and immune pathways.
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4
In vitro experiments demonstrated that naringenin and MAPK1 knockdown improved cell viability and reduced inflammatory cytokines IL-6, IL-17, and TNF-α.
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5
The findings support the clinical application of TCM in NP, highlighting naringenin's therapeutic effects through targeting MAPK1 and regulating inflammation.
