2025 ESMO Prostate Cancer Highlights - Takeaways - MDSpire

2025 ESMO Prostate Cancer Highlights

  • November 17, 2025

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  • 1

    The ESMO 2025 updates highlight the role of enzalutamide in high-risk localized prostate cancer and its impact on metastasis-free survival.

  • 2

    The NZRAD trial found no overall survival benefit from adding enzalutamide to ADT and radiation for most localized prostate cancer patients.

  • 3

    Patients with node-positive disease showed improved metastasis-free survival when treated with enzalutamide, suggesting a tailored approach is necessary.

  • 4

    The Embark study demonstrated that enzalutamide plus ADT significantly improves overall survival in high-risk biochemical relapse prostate cancer.

  • 5

    Adverse events were higher in enzalutamide treatment arms, emphasizing the need for careful patient selection and monitoring.

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