Cross-modal fusion of cytomorphology and 18F-FDG PET/CT for non-invasive bone marrow immune microenvironment decoding in multiple myeloma - Takeaways - MDSpire

Cross-modal fusion of cytomorphology and 18F-FDG PET/CT for non-invasive bone marrow immune microenvironment decoding in multiple myeloma

  • By

  • Minjie Gao

  • Guifang Ouyang

  • Yangguang Liu

  • Shikun Chen

  • Kaihong Xu

  • June 24, 2026

  • 0 min

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  • 1

    ImmunoCast-MM integrates cytomorphological analysis and 18F-FDG PET/CT imaging for assessing the bone marrow immune microenvironment in multiple myeloma.

  • 2

    The framework classifies individual cells and generates an Immune Dysfunction Index (IDI) to evaluate immune competence in newly diagnosed multiple myeloma patients.

  • 3

    Cytomorphologic indices correlated with flow cytometric measurements, showing strong statistical significance in a validation subset of 243 patients.

  • 4

    Unsupervised clustering identified immune-competent and immune-exhausted archetypes, impacting progression-free survival and response to daratumumab.

  • 5

    Incorporating the IDI improved risk assessment and response prediction for daratumumab, enhancing the concordance index and area under the ROC curve.

Original Source(s)

Cross-modal fusion of cytomorphology and 18F-FDG PET/CT for non-invasive bone marrow immune microenvironment decoding in multiple myeloma

  • by Minjie Gao, Guifang Ouyang, Yangguang Liu, Shikun Chen, Kaihong Xu

  • June 24, 2026

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