Distinctive Liver Function in Individuals with High Myopia: Links to Myopic Macular Degeneration - Takeaways - MDSpire

Distinctive Liver Function in Individuals with High Myopia: Links to Myopic Macular Degeneration

  • By

  • Yujun Pei

  • Jiaqi Meng

  • Wenwen He

  • Keke Zhang

  • Dongling Guo

  • Yi Lu

  • Xiangjia Zhu

  • November 28, 2025

  • 0 min

Share

  • 1

    High myopia is defined by an axial length of the eye ≥ 26 mm and is associated with severe ocular complications like macular degeneration.

  • 2

    The liver plays a crucial role in metabolic processes and may influence eye health through liver-derived hormones and metabolites.

  • 3

    Systemic metabolic disturbances and oxidative stress are linked to the progression of myopia and may affect retinal physiology.

  • 4

    This study analyzed liver function and lipid indexes in high myopic patients to explore their associations with axial length and myopic macular degeneration.

  • 5

    The findings aim to provide preliminary evidence for a liver-eye metabolic axis and its potential role in myopic progression.

Original Source(s)

Distinctive Liver Function in Individuals with High Myopia: Links to Myopic Macular Degeneration

  • by Yujun Pei, Jiaqi Meng, Wenwen He, Keke Zhang, Dongling Guo, Yi Lu, Xiangjia Zhu

  • November 28, 2025

Related Content

Diabetic Retinal Disease Rates Narrow by Diabetes Type

US claims data showed rising prevalence of diabetic retinal disease in type 1 and type 2 diabetes, while incidence declined in type 1 diabetes and moved closer to type 2 rates by 2022.

Combination Therapy May Increase Lesion Closure in PCV

The combination of photodynamic therapy and intravitreal  aflibercept did not improve 1-year visual acuity outcomes compared with aflibercept monotherapy.

Single-cell transcriptomic profiling uncovers pathogenic cellular diversity and potential inflammatory markers in the retinas of STZ-induced diabetic mice