Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children - Takeaways - MDSpire

Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children

  • By

  • Sergey Yegorov

  • Angela Brewer

  • Louis Cyr

  • Brian J Ward

  • Eleanor Pullenayegum

  • Matthew S Miller

  • Mark Loeb

  • November 6, 2024

  • 0 min

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  • 1

    Hemagglutinin-inhibiting antibodies are crucial for immune defense against influenza, particularly in children.

  • 2

    Postvaccination HAI titers significantly correlate with reduced risk of confirmed influenza in children.

  • 3

    Both live attenuated and inactivated influenza vaccines elicit HAI antibodies that provide protection against matched influenza strains.

  • 4

    The study demonstrated that HAI titers can serve as a reliable correlate of protection for both LAIV and IIV in children.

  • 5

    HAI titers were lower in the LAIV group, yet both vaccine types showed effectiveness against subtype-matched influenza.

Original Source(s)

Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children

  • by Sergey Yegorov, Angela Brewer, Louis Cyr, Brian J Ward, Eleanor Pullenayegum, Matthew S Miller, Mark Loeb

  • November 6, 2024

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