Uric Acid Stone Dissolution Peaked at pH 7.2 - Takeaways - MDSpire
From the Journals

Uric Acid Stone Dissolution Peaked at pH 7.2

In vitro study found dissolution rates increased sharply above pH 6.5 and were tenfold higher after stone fragmentation.

  • By

  • Mouj Hijazi

  • May 12, 2026

  • 4 min

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  • 1

    Optimal urine pH for uric acid stone dissolution is 7.0 to 7.

  • 2

    Ground stones dissolve at rates tenfold higher than intact stones.

  • 3

    Potassium citrate is less likely to encourage calcium phosphate formation.

  • 4

    EAU recommends a pH range of 6.5 to 7.

  • 5

    Sodium bicarbonate may hinder dissolution by forming sodium urate shells.

  • 6

    Further clinical studies are necessary to validate findings.

Original Source(s)

Uric Acid Stone Dissolution Peaked at pH 7.2

  • by Mouj Hijazi

  • May 12, 2026

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