Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel - Takeaways - MDSpire

Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel

  • By

  • Lubna Q. Khasawneh

  • Mais N. Alqasrawi

  • Zeina N. Al-Mahayri

  • Lilas Dabaghie

  • Sahar M. Altoum

  • Gohar Jamil

  • Salahdein Aburuz

  • Dana Hamza

  • Lizy George

  • Faiz Al-Bakshy

  • Kaes Al-Anee

  • Khuzama AlAhamad

  • Fatma Al-Maskari

  • Husam Ouda

  • Juma AlKaabi

  • George P. Patrinos

  • Bassam R. Ali

  • June 24, 2026

  • 0 min

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  • 1

    The study evaluated the impact of ABCB1 and CYP2C19 genetic variants on major adverse cardiovascular events in clopidogrel-treated patients with acute coronary syndrome.

  • 2

    A total of 174 patients from the UAE were included, with genotyping for ABCB1 and CYP2C19 variants performed using real-time PCR TaqMan assays.

  • 3

    The presence of ABCB1 alleles showed no significant correlation with major adverse cardiovascular events, regardless of genetic models used.

  • 4

    CYP2C19*2 variant indicated a weak trend towards increased risk of major adverse cardiovascular events, but results were not statistically significant.

  • 5

    The study concluded that common ABCB1 variants do not predict outcomes in clopidogrel-treated patients with acute coronary syndrome.

Original Source(s)

Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel

  • by Lubna Q. Khasawneh, Mais N. Alqasrawi, Zeina N. Al-Mahayri, Lilas Dabaghie, Sahar M. Altoum, Gohar Jamil, Salahdein Aburuz, Dana Hamza, Lizy George, Faiz Al-Bakshy, Kaes Al-Anee, Khuzama AlAhamad, Fatma Al-Maskari, Husam Ouda, Juma AlKaabi, George P. Patrinos, Bassam R. Ali

  • June 24, 2026

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