External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease - Takeaways - MDSpire

External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease

  • By

  • Shi, Haoke

  • Yang, Lihua

  • Fang, Yijie

  • Lu, Hongping

  • Huang, Yangyang

  • Xiao, Zhiyong

  • Long, Yongxin

  • Li, Peng

  • Shi, Fengzhi

  • Liao, Hongwu

  • Yin, Xinhong

  • May 19, 2026

  • 0 min

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  • 1

    Depression in older adults with heart disease is heterogeneous and often assessed using total symptom scores.

  • 2

    The study analyzed 1,685 participants from the China Health and Retirement Longitudinal Study and 506 from an independent cohort.

  • 3

    Multimorbidity burden, caregiving status, and sex were associated with local patterns in the depressive symptom-biomarker network.

  • 4

    Depressed mood consistently showed the highest centrality among symptom nodes across both cohorts.

  • 5

    The findings support integrating external factors and biomarkers to better characterize depressive heterogeneity in this population.

Original Source(s)

External factors show reproducible local symptom-biomarker associations in middle-aged and older adults with heart disease

  • by Shi, Haoke , Yang, Lihua , Fang, Yijie , Lu, Hongping , Huang, Yangyang , Xiao, Zhiyong , Long, Yongxin , Li, Peng , Shi, Fengzhi , Liao, Hongwu , Yin, Xinhong

  • May 19, 2026

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