Sinonasal and skull base phosphaturic mesenchymal tumours: a case series and narrative review - Takeaways - MDSpire

Sinonasal and skull base phosphaturic mesenchymal tumours: a case series and narrative review

  • By

  • Genwang Pei

  • Rongfeng Lin

  • Guangqi Li

  • Yinyan Lai

  • June 18, 2026

  • 0 min

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  • 1

    Phosphaturic mesenchymal tumours (PMTs) are rare in the sinonasal region and skull base, often leading to diagnostic challenges and misdiagnoses.

  • 2

    The study analyzed five patients with sinonasal/skull base PMTs, highlighting a mean diagnostic delay of three years from symptom onset to identification.

  • 3

    All patients presented with bone pain and pathological fractures, with nasal symptoms reported in three cases, complicating the clinical picture.

  • 4

    Key diagnostic tools included PET imaging showing somatostatin receptor positivity and immunohistochemistry confirming SSTR2+/SATB2+ expression.

  • 5

    Postoperative serum phosphorus levels normalized in all patients, indicating effective management of PMTs after surgical resection.

Original Source(s)

Sinonasal and skull base phosphaturic mesenchymal tumours: a case series and narrative review

  • by Genwang Pei, Rongfeng Lin, Guangqi Li, Yinyan Lai

  • June 18, 2026

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