Preoperative Inflammatory-Lymphocyte Recovery Profile and Its Association with Pathological Outcomes in Resected Osteosarcoma: A Retrospective Analysis

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In a study of 162 osteosarcoma patients, 54.3% exhibited poor pathological response after neoadjuvant chemotherapy.
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Patients were categorized into three recovery phenotypes: favorable recovery, intermediate recovery, and persistent recovery failure.
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Persistent recovery failure was significantly associated with poor pathological response, with an odds ratio of 5.72.
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The standardized risk of poor pathological response was 75.7% in the persistent failure group compared to 37.2% in the favorable recovery group.
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The study suggests that preoperative inflammatory-lymphocyte recovery phenotype may be linked to pathological outcomes in osteosarcoma.

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