Exploratory metabolomic analysis for identifying systemic signatures of Helicobacter pylori infection in children

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Helicobacter pylori infection can lead to serious gastrointestinal conditions, including gastritis, ulcers, and gastric cancer.
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This study analyzed serum metabolomic biomarkers in 32 H. pylori-infected children and 32 healthy controls to identify differences.
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Seven metabolites were found to differentiate H. pylori-infected children from uninfected ones, linked to immune regulation and metabolism.
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The identified metabolites may indicate systemic effects of H. pylori infection, but further validation is needed for clinical relevance.
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Current diagnostic methods for H. pylori include urea breath tests and histological examinations, with varying effectiveness in children.

Frontiers In Immunology

by Weronika Gonciarz, Lucyna Kozlowska, Marta Stelmasiak, Magdalena Wozniczka, Magdalena Chmiela
June 16, 2026

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