Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial - Takeaways - MDSpire

Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial

  • By

  • Jack A Helliwell

  • Caroline H Chilton

  • Caroline Young

  • Emma V Clark

  • Lyndsay Wilkinson

  • Alba Fuentes Balaguer

  • Daniel Bottomley

  • Julie Croft

  • Neil Corrigan

  • Andrew Kirby

  • Philip Quirke

  • Deborah D Stocken

  • David G Jayne

  • Henry M Wood

  • September 30, 2025

  • 0 min

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  • 1

    The study analyzed microbiome changes in 202 rectal cancer surgery patients during the NIHR IntAct trial.

  • 2

    Factors like smoking, hospital site, and preoperative antibiotics significantly influenced microbiome diversity.

  • 3

    Alpha-diversity decreased post-surgery, with increases in Enterococcus and Prevotella observed.

  • 4

    No significant differences in microbiome diversity were found between patients with and without anastomotic leaks.

  • 5

    The findings highlight the need for further research on the clinical significance of microbiome changes post-surgery.

Original Source(s)

Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial

  • by Jack A Helliwell, Caroline H Chilton, Caroline Young, Emma V Clark, Lyndsay Wilkinson, Alba Fuentes Balaguer, Daniel Bottomley, Julie Croft, Neil Corrigan, Andrew Kirby, Philip Quirke, Deborah D Stocken, David G Jayne, Henry M Wood

  • September 30, 2025

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