Successful outcomes of pediatric dacryocystorhinostomy with adjunctive 5-fluorouracil - Takeaways - MDSpire

Positive Results of Pediatric Dacryocystorhinostomy Enhanced by Intraoperative 5-Fluorouracil

  • By

  • Alina K. Sinha

  • Ethan L. Kahana

  • Tomas E. Meijome

  • Adam Jacobson

  • Jane Z. Spadaro

  • Stella Y. Chung

  • Alon Kahana

  • July 17, 2026

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  • 1

    The study assessed the impact of nasal intramucosal 5-fluorouracil (5-FU) on outcomes of pediatric dacryocystorhinostomy (DCR) for nasolacrimal duct obstruction.

  • 2

    Sixteen pediatric patients underwent DCR with 5-FU injection, resulting in a 100% success rate for preventing epiphora recurrence.

  • 3

    Ten of the 19 eyes treated were in patients with craniofacial syndromes, highlighting a population at higher risk for recurrence.

  • 4

    The study reported no post-operative complications associated with the use of 5-FU in this small sample size.

  • 5

    The findings suggest that adjuvant 5-FU may be beneficial in improving DCR outcomes, particularly in high-risk pediatric patients.

Original Source(s)

Successful outcomes of pediatric dacryocystorhinostomy with adjunctive 5-fluorouracil

  • by Alina K. Sinha, Ethan L. Kahana, Tomas E. Meijome, Adam Jacobson, Jane Z. Spadaro, Stella Y. Chung, Alon Kahana

  • July 17, 2026

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