Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review - Takeaways - MDSpire

Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review

  • By

  • Miaojun Mo

  • Linlin Chen

  • Yi Wang

  • Xinyu Lin

  • Haiting Li

  • Binbin Chen

  • Junhui Yuan

  • Enfu Tao

  • April 22, 2026

  • 0 min

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  • 1

    The gut-lung axis connects early microbial programming to respiratory health, influencing childhood asthma development.

  • 2

    Perinatal factors like maternal diet and antibiotic exposure shape gut microbiota, impacting immune system education.

  • 3

    Microbial metabolites, particularly short-chain fatty acids, play crucial roles in regulating immune responses and airway inflammation.

  • 4

    Dysbiosis, marked by delayed microbial maturation, compromises immune balance and increases asthma susceptibility.

  • 5

    Microbiome-targeted therapies, including probiotics and fecal microbiota transplantation, show promise for asthma management.

Original Source(s)

Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review

  • by Miaojun Mo, Linlin Chen, Yi Wang, Xinyu Lin, Haiting Li, Binbin Chen, Junhui Yuan, Enfu Tao

  • April 22, 2026

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