Predictive value of NRI, NLR, PLR and LMR for therapeutic efficacy and prognosis in advanced rectal cancer patients treated with PD-1/PD-L1 immunotherapy - Takeaways - MDSpire

Predictive value of NRI, NLR, PLR and LMR for therapeutic efficacy and prognosis in advanced rectal cancer patients treated with PD-1/PD-L1 immunotherapy

  • By

  • Mengli Gao

  • Zhe Gao

  • Yanan Wang

  • Wenguang Song

  • May 28, 2026

  • 0 min

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  • 1

    The study evaluated the predictive value of NRI, NLR, PLR, and LMR for treatment outcomes in advanced rectal cancer patients undergoing immunotherapy.

  • 2

    A total of 172 patients were analyzed, with optimal cut-off values for NLR, PLR, LMR, and NRI determined by ROC curves.

  • 3

    Patients with low NLR, low PLR, high LMR, and high NRI showed significantly higher objective response rates and disease control rates.

  • 4

    High NLR and high PLR were associated with significantly shorter median progression-free survival and overall survival.

  • 5

    Multivariate analysis identified TNM stage Ⅳ and high NLR as independent risk factors for poor prognosis in advanced rectal cancer.

Original Source(s)

Predictive value of NRI, NLR, PLR and LMR for therapeutic efficacy and prognosis in advanced rectal cancer patients treated with PD-1/PD-L1 immunotherapy

  • by Mengli Gao, Zhe Gao, Yanan Wang, Wenguang Song

  • May 28, 2026

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