Chronic Pain as a Disorder of Brain Network Dynamics: A Systems Model Incorporating Physiological Regulation and Self-Organization

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Chronic pain is recognized as a disorder of brain network organization, involving alterations in the salience network, default mode network, and central executive network.
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Neuroimaging studies show that persistent pain is linked to increased salience network activity and altered connectivity in the default mode network.
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The proposed state-constrained triple-network model incorporates physiological regulation, suggesting it shapes chronic pain network dynamics.
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Chronic pain may arise from interactions between physiological regulation and brain network dynamics, influencing pain-related network states over time.
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The model emphasizes the importance of physiological context in understanding the stability and variability of chronic pain experiences.

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