LC–MS-based serum metabolomics reveals distinct metabolic signatures in patients with intracerebral Hemorrhage

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Intracerebral hemorrhage (ICH) is a severe neurological condition with high mortality and significant impact on patients' quality of life.
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The study identified 3,178 metabolites in serum samples from patients with and without ICH using liquid chromatography-mass spectrometry (LC–MS).
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Benzene derivatives and organic acids were the most abundant metabolites in ICH patients, while amino acids and lipid metabolites were decreased.
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KEGG pathway enrichment analysis indicated significant involvement of various metabolic pathways related to ICH.
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ROC analysis demonstrated excellent diagnostic performance for several metabolites, including Dibutyl phthalate and Octadecanamide.

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