Mortality trends from colorectal pathologies in the United States (1999–2020): a retrospective cohort study using CDC WONDER

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Colorectal pathologies accounted for 2.7% of US deaths from 1999 to 2020, with colorectal cancer (CRC) being the leading cause of mortality.
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Mortality from benign colorectal conditions was significantly higher than from inflammatory bowel disease (IBD) throughout the study period.
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The leading causes of death among benign colorectal conditions included Clostridioides difficile enterocolitis and diverticular disease.
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CRC mortality declined over time, while mortality from benign colorectal conditions and IBD remained stable with slight annual increases.
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The study highlights a public health gap, as benign colorectal conditions have not received equivalent research attention compared to CRC.

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