Exploring the Clinical Features and Proteomic Profile of Relapsing Polychondritis with Respiratory Complications

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Relapsing polychondritis (RP) is a rare autoimmune disease that causes recurrent inflammation and damage to cartilage.
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Respiratory involvement in RP is a major cause of mortality and often presents with symptoms similar to chronic respiratory diseases.
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Seventy-seven RP patients with respiratory involvement were analyzed, revealing distinct clinical characteristics and bronchoscopic findings.
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Latent class analysis identified three subgroups of patients based on bronchoscopic manifestations and airway involvement.
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Proteomic analysis indicated that complement and neutrophil extracellular trap-related proteins may contribute to the pathogenesis of respiratory-involved RP.

Frontiers In Immunology

by Xia Fang, Ximing Liao, Wei Gao, Wei Pei, Wujian Xu, Yuanyuan Wang, Yin Wu, Rongzhang Chen, Jiajun Ding, Muyun Wang, Xingyan Zhu, Heng Zhang, Dan-ni Ren, Qiang Li, Shaoyong Gao
July 17, 2026

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