Raman Spectroscopy Moves to the Front Line of Pandemic Preparedness
Comprehensive review highlights label-free viral detection – and the hurdles to real-world deployment
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Raman spectroscopy offers rapid, label-free molecular fingerprinting of viruses and host responses, enhancing virology diagnostics.
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Enhanced Raman techniques like SERS, TERS, and CARS improve sensitivity and resolution for real-time detection of viral interactions.
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Raman-based methods have shown rapid detection capabilities for influenza and SARS-CoV-2 with high accuracy in complex samples.
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Research focus is skewed towards high-impact viruses, leaving high-risk pathogens like Lassa and Marburg underexplored.
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Technical challenges such as weak signal intensity and regulatory hurdles hinder the clinical translation of Raman spectroscopy.
