Smad4 and Eomes converge on a shared transcriptional program associated with inflammatory CD8 T-cell differentiation - Takeaways - MDSpire
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Smad4 and Eomes Interact in a Common Transcriptional Pathway Linked to Inflammatory CD8 T-Cell Differentiation

  • By

  • Karthik Chandiran

  • Nandu C. Karingari

  • Srineeharika Sirigineedi

  • Linda S. Cauley

  • August 17, 2026

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  • 1

    Smad4 and Eomes are critical transcription factors influencing CD8 T cell differentiation and protective immunity.

  • 2

    Disruption of transcriptional pathways regulated by Smad4 and Eomes is linked to viral infections, chronic inflammation, and cancer.

  • 3

    Smad4 and Eomes are essential for the differentiation of memory T cells, particularly tissue-resident memory (TRM) cells.

  • 4

    An integrated analysis revealed overlapping and unique gene expression programs regulated by Smad4 and Eomes in CD8 T cells.

  • 5

    Canonical TGF-beta signaling remains active without Smad4 or Eomes, becoming inactive only when both Smad3 and Smad4 are absent.

Original Source(s)

Smad4 and Eomes converge on a shared transcriptional program associated with inflammatory CD8 T-cell differentiation

  • by Karthik Chandiran, Nandu C. Karingari, Srineeharika Sirigineedi, Linda S. Cauley

  • August 17, 2026

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