Case Report: Pediatric Philadelphia chromosome-positive T-lymphoblastic leukemia relapsing as chronic-phase CML after treatment discontinuation - Takeaways - MDSpire

Case Report: Pediatric Philadelphia chromosome-positive T-lymphoblastic leukemia relapsing as chronic-phase CML after treatment discontinuation

  • By

  • Rongrong Dong

  • Xinying Dai

  • Yuan Feng

  • July 7, 2026

  • 0 min

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  • 1

    A 14-year-old boy was diagnosed with de novo Philadelphia chromosome-positive T-lymphoblastic leukemia (T-ALL) after presenting with fever and leukocytosis.

  • 2

    Bone marrow examination revealed 81% blasts, confirming T-ALL, and cytogenetic analysis detected a BCR::ABL1 fusion transcript.

  • 3

    The patient achieved complete remission following induction chemotherapy with VICP and imatinib but declined further treatment options.

  • 4

    After self-discontinuing imatinib for 18 months, the patient developed chronic myeloid leukemia (CML), suggesting initial misclassification.

  • 5

    This case emphasizes the diagnostic challenges between de novo Ph-positive T-ALL and T-lymphoid blast-phase CML, impacting treatment decisions.

Original Source(s)

Case Report: Pediatric Philadelphia chromosome-positive T-lymphoblastic leukemia relapsing as chronic-phase CML after treatment discontinuation

  • by Rongrong Dong, Xinying Dai, Yuan Feng

  • July 7, 2026

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