Osteoarthritis as a systemic disorder: multi-organ crosstalk in pathogenesis and therapeutic targeting - Takeaways - MDSpire

Osteoarthritis as a systemic disorder: multi-organ crosstalk in pathogenesis and therapeutic targeting

  • By

  • Tao Shu

  • Xiaobin Shang

  • Yan Zhou

  • July 8, 2026

  • 0 min

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  • 1

    Osteoarthritis (OA) is increasingly recognized as a systemic disorder involving multiple organs rather than solely a localized joint disease.

  • 2

    The review proposes the 'Gut-Brain-Liver-Kidney axis' as a framework to explore systemic factors in OA pathogenesis.

  • 3

    Gut microbiota dysbiosis and its metabolites contribute to systemic inflammation and disrupt joint homeostasis in OA.

  • 4

    Central sensitization and neuroendocrine dysregulation in the brain significantly influence chronic pain perception in OA.

  • 5

    The review outlines potential therapeutic strategies targeting systemic pathways, including probiotics and vitamin D supplementation.

Original Source(s)

Osteoarthritis as a systemic disorder: multi-organ crosstalk in pathogenesis and therapeutic targeting

  • by Tao Shu, Xiaobin Shang, Yan Zhou

  • July 8, 2026

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