POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population

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Loss-of-function mutations in POU3F2 are linked to neurodevelopmental disorders, including autism spectrum disorder.
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POU3F2 disruption in neural progenitor cells reduces canonical Wnt signaling and decreases cell proliferation.
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POU3F2 positively associates with Wnt signaling and negatively with radial glia specification in diverse NPCs.
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SOX13 and ADNP are identified as transcriptional targets of POU3F2, mediating its effects on Wnt signaling.
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The study highlights POU3F2's role in regulating neurodevelopment and its connection to autism pathogenesis.

Brain

by Courtney R Benoit, Lilia B Sattler, Aimee J Aylward, Olivia Pembridge, Bella Kim, Christina R Muratore, Meichen Liao, Amy He, Nancy Ashour, Seeley B Fancher, Alexandra M Lish, Richard V Pearse, Joseph D Buxbaum, Tracy L Young-Pearse
June 11, 2025

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