POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population - Takeaways - MDSpire
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POU3F2 Modulates Canonical Wnt Pathway Through SOX13 and ADNP to Enhance Neural Progenitor Cell Expansion

  • By

  • Courtney R Benoit

  • Lilia B Sattler

  • Aimee J Aylward

  • Olivia Pembridge

  • Bella Kim

  • Christina R Muratore

  • Meichen Liao

  • Amy He

  • Nancy Ashour

  • Seeley B Fancher

  • Alexandra M Lish

  • Richard V Pearse

  • Joseph D Buxbaum

  • Tracy L Young-Pearse

  • June 11, 2025

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  • 1

    Loss-of-function mutations in POU3F2 are linked to neurodevelopmental disorders, including autism spectrum disorder.

  • 2

    POU3F2 disruption in neural progenitor cells reduces canonical Wnt signaling and decreases cell proliferation.

  • 3

    POU3F2 positively associates with Wnt signaling and negatively with radial glia specification in diverse NPCs.

  • 4

    SOX13 and ADNP are identified as transcriptional targets of POU3F2, mediating its effects on Wnt signaling.

  • 5

    The study highlights POU3F2's role in regulating neurodevelopment and its connection to autism pathogenesis.

Original Source(s)

POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population

  • by Courtney R Benoit, Lilia B Sattler, Aimee J Aylward, Olivia Pembridge, Bella Kim, Christina R Muratore, Meichen Liao, Amy He, Nancy Ashour, Seeley B Fancher, Alexandra M Lish, Richard V Pearse, Joseph D Buxbaum, Tracy L Young-Pearse

  • June 11, 2025

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