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Gut Microbiota-Driven Secondary Bile Acid Synthesis Enhances Colorectal Cancer Risk Linked to Western Dietary Patterns

  • By

  • Annika Osswald

  • Esther Wortmann

  • David Wylensek

  • Stephanie Kuhls

  • Olivia I Coleman

  • Kenneth Peuker

  • Anne Strigli

  • Quinten R Ducarmon

  • Martin Larralde

  • Wei Liang

  • Nicole S Treichel

  • Fabian Schumacher

  • Colin Volet

  • Silke Matysik

  • Karin Kleigrewe

  • Michael Gigl

  • Sascha Rohn

  • Chun-Jun Guo

  • Burkhard Kleuser

  • Gerhard Liebisch

  • Angelika Schnieke

  • Jason M Ridlon

  • Rizlan Bernier-Latmani

  • Georg Zeller

  • Sebastian Zeissig

  • Dirk Haller

  • Krzysztof Flisikowski

  • Thomas Clavel

  • Soeren Ocvirk

  • August 1, 2026

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  • 1

    Western diet is linked to increased colorectal cancer (CRC) risk due to its association with elevated secondary bile acids (BAs).

  • 2

    In APC 1311/+ pigs, a Western diet exacerbates colorectal tumorigenesis, showing a causal relationship between diet and CRC development.

  • 3

    Increased levels of deoxycholic acid (DCA) correlate with enhanced epithelial cell proliferation in the colon, which can be reversed by colestyramine.

  • 4

    Colonization of gnotobiotic mice with 7α-dehydroxylating bacteria leads to increased DCA production and promotes colonic epithelial cell proliferation.

  • 5

    Specific detection of 7αDH+ bacteria in human stool may help identify individuals at high risk for CRC associated with Western dietary patterns.

Original Source(s)

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

  • by Annika Osswald, Esther Wortmann, David Wylensek, Stephanie Kuhls, Olivia I Coleman, Kenneth Peuker, Anne Strigli, Quinten R Ducarmon, Martin Larralde, Wei Liang, Nicole S Treichel, Fabian Schumacher, Colin Volet, Silke Matysik, Karin Kleigrewe, Michael Gigl, Sascha Rohn, Chun-Jun Guo, Burkhard Kleuser, Gerhard Liebisch, Angelika Schnieke, Jason M Ridlon, Rizlan Bernier-Latmani, Georg Zeller, Sebastian Zeissig, Dirk Haller, Krzysztof Flisikowski, Thomas Clavel, Soeren Ocvirk

  • August 1, 2026

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