Motor recovery through perineuronal net modulation in a Parkinson’s disease mouse model

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Transient reduction of perineuronal nets in the primary motor cortex leads to temporary motor function deficits in healthy mice.
2

In a Parkinson's disease mouse model, perineuronal net levels decrease post-midbrain lesion but return to baseline within five weeks.
3

Chondroitinase ABC treatment can enhance motor recovery when combined with motor stimulation in Parkinson's disease models.
4

Motor recovery is linked to increased parvalbumin interneurons and rebalancing of excitatory synaptic markers after PNN reduction.
5

Perineuronal nets in the primary motor cortex are potential therapeutic targets for improving motor function in neurodegenerative diseases.

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