Rather a versatile multi-tool than a sword: an integral role of the plasminogen system in health and disease

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The plasminogen system regulates vital physiological processes such as fibrinolysis, inflammation, wound healing, and tissue remodeling.
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Dysregulation of the plasminogen system can lead to various pathologies, including hereditary disorders, cancer, and infections.
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Plasminogen is a zymogen that is activated by tissue-type and urokinase-type plasminogen activators to form the active protease plasmin.
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The plasminogen system has evolved alongside the coagulation system, indicating its role in regulating clot formation and dissolution.
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Components of the plasminogen system are being explored as potential therapeutic targets due to their multifaceted roles in health and disease.

Frontiers In Immunology

by Rostislav Skrabana, Maja Castven, Maria Tomková, Erik Sedlák, Patrik Babulic, Michaela Jakubcova, Tetiana Moskalets, Vladimir Leksa
July 3, 2026

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