Early Proteomic and Metabolomic Signatures in Diabetes Associated with Progression to Diabetic Retinopathy Over 1–2 Years - Takeaways - MDSpire

Early Proteomic and Metabolomic Signatures in Diabetes Associated with Progression to Diabetic Retinopathy Over 1–2 Years

  • By

  • Zhao, Jing

  • Cao, Yitao

  • Chai, Zhi

  • Xie, Hanghang

  • Gu, Dandan

  • Yanchun, Zhang

  • Dongling, Niu

  • Liu, Hongli

  • Lei, Ting

  • May 29, 2026

  • 0 min

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  • 1

    The study analyzed proteomic and metabolomic changes in plasma samples from 15 diabetes patients who developed diabetic retinopathy within 1–2 years.

  • 2

    Proteomic analysis identified 57 differentially expressed proteins related to energy metabolism, detoxification, and cellular defense responses.

  • 3

    Metabolomic profiling revealed 168 differential metabolites, focusing on taurine metabolism, neuroactive ligand-receptor interaction, and tyrosine metabolism.

  • 4

    Eight candidate proteins were validated, including three previously known in diabetic retinopathy and five newly identified candidates.

  • 5

    ROC analysis showed strong discriminative performance for the validated proteins, with AUC values between 0.853 and 0.945.

Original Source(s)

Early Proteomic and Metabolomic Signatures in Diabetes Associated with Progression to Diabetic Retinopathy Over 1–2 Years

  • by Zhao, Jing , Cao, Yitao , Chai, Zhi , Xie, Hanghang , Gu, Dandan , Yanchun, Zhang , Dongling, Niu , Liu, Hongli , Lei, Ting

  • May 29, 2026

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