Combination Therapy Targets Bacterial Keratitis
Study examines antimicrobial and anti-inflammatory benefits of combined levofloxacin and ibuprofen for Staphylococcus aureus-induced keratitis
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A combination of levofloxacin and ibuprofen may enhance treatment for bacterial keratitis amid rising antimicrobial resistance.
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In a rat model, combination therapy outperformed monotherapy in microbiological, molecular, and histological assessments.
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Ibuprofen reduced the minimum inhibitory concentration of levofloxacin, indicating enhanced antibacterial potency.
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Combination therapy resulted in lower inflammatory cytokine expression and improved corneal architecture compared to monotherapy.
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The study's findings are exploratory, limited by small sample size and focus on Staphylococcus aureus, necessitating further research.
