Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial - Takeaways - MDSpire

Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial

  • By

  • Gazi Saadmaan

  • Maria Carolina Dalmasso

  • Maleeha Maria

  • Jenni Lehtisalo

  • Mikko Hiltunen

  • Minna U Kaikkonen

  • Esko Levälahti

  • Francesca Mangialasche

  • Markus Perola

  • Alfredo Ramirez

  • Ruth Stephen

  • Tiia Ngandu

  • Miia Kivipelto

  • Alina Solomon

  • August 6, 2025

  • 0 min

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  • 1

    The FINGER trial involved 1259 at-risk individuals aged 60–77, randomized to a multidomain lifestyle intervention or regular health advice.

  • 2

    Cognitive benefits were observed in participants with higher Alzheimer's disease genetic risk scores (AD-GRS) compared to those with lower scores.

  • 3

    The study found no significant overall relationship between AD-GRS or CAD-GRS and the intervention effect, but gender differences were noted for AD-GRS.

  • 4

    Higher-risk females showed greater cognitive improvement from the intervention than lower-risk females, while results were less pronounced for males.

  • 5

    Findings suggest that individuals with genetic susceptibility for Alzheimer's or coronary artery disease can benefit from lifestyle interventions.

Original Source(s)

Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial

  • by Gazi Saadmaan, Maria Carolina Dalmasso, Maleeha Maria, Jenni Lehtisalo, Mikko Hiltunen, Minna U Kaikkonen, Esko Levälahti, Francesca Mangialasche, Markus Perola, Alfredo Ramirez, Ruth Stephen, Tiia Ngandu, Miia Kivipelto, Alina Solomon

  • August 6, 2025

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