saRNA Injection Targets Cardiac Injury
Preclinical study shows saRNA therapy improved cardiac function and reduced infarct size after myocardial infarction
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Researchers developed a self-amplifying RNA (saRNA) therapy for heart recovery after myocardial infarction.
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The therapy uses a lipid nanoparticle for a single intramuscular injection, enabling sustained hormone production.
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saRNA delivers instructions for natriuretic peptide type A, promoting cardiovascular regulation.
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In preclinical models, a single injection improved cardiac function and reduced infarct size for over 4 weeks.
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The researchers aim to study safety and dosing before advancing to human trials.
