Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hematological patients with severe iatrogenic immunosuppression - Takeaways - MDSpire

Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hematological patients with severe iatrogenic immunosuppression

  • By

  • Emmanouil Karofylakis

  • Theodoros Loupis

  • Andromachi Blizou

  • Eleni Ntalaouti

  • Eirini Maria Stergioti

  • Giannis Vatsellas

  • Sotirios Tsiodras

  • Anastasia Antoniadou

  • Aggelos Banos

  • Konstantinos Thomas

  • April 30, 2026

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  • 1

    Immunocompromised patients with B-cell depletion are at risk for prolonged SARS-CoV-2 replication and unique intrahost mutations.

  • 2

    A significant proportion of patients in the study experienced relapsing COVID-19, highlighting the severity of their condition.

  • 3

    Thirty mutations in the spike gene were identified, with a prevalence of less than 0.1%, indicating ongoing viral evolution.

  • 4

    The study found a statistically significant accumulation of intrahost single nucleotide variants (iSNVs) correlated with infection duration.

  • 5

    No significant difference in substitution rates was observed between patients with rheumatic and hematologic conditions.

Original Source(s)

Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hematological patients with severe iatrogenic immunosuppression

  • by Emmanouil Karofylakis, Theodoros Loupis, Andromachi Blizou, Eleni Ntalaouti, Eirini Maria Stergioti, Giannis Vatsellas, Sotirios Tsiodras, Anastasia Antoniadou, Aggelos Banos, Konstantinos Thomas

  • April 30, 2026

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