Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation - Takeaways - MDSpire

Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation

  • By

  • Maoqin Tian

  • Sheng Wan

  • Hao Gao

  • Yinghui Yin

  • Feng Han

  • Yong Yang

  • Zhenzhong Liu

  • Qihan Zhao

  • Shaoxin Huang

  • May 25, 2026

  • 0 min

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  • 1

    Cadmium exposure is linked to anxiety, with a study identifying 120 differentially expressed proteins associated with this condition.

  • 2

    A ginseng and mulberry leaf decoction was prioritized through network pharmacology and shown to reverse anxiety-like behavior in cadmium-exposed rats.

  • 3

    Molecular docking revealed strong binding of quercetin and kaempferol to key proteins AKT1, PTGS2, and HSP90AA1.

  • 4

    The decoction improved exploratory behavior in rats without affecting locomotion and reduced neurovascular and glial pathology.

  • 5

    This research suggests a multi-target intervention approach for cadmium-induced neurotoxicity, warranting further studies on dosage and mechanisms.

Original Source(s)

Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation

  • by Maoqin Tian, Sheng Wan, Hao Gao, Yinghui Yin, Feng Han, Yong Yang, Zhenzhong Liu, Qihan Zhao, Shaoxin Huang

  • May 25, 2026

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