Metabolomic biomarker differences of sarcopenia in older patients with sepsis - Takeaways - MDSpire

Metabolomic biomarker differences of sarcopenia in older patients with sepsis

  • By

  • Yiyang Liu

  • Tianren He

  • Siyu Chen

  • Ziyi Li

  • Xue Mei

  • Xinhua He

  • Na Shang

  • April 30, 2026

  • 0 min

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  • 1

    Sarcopenia significantly affects older patients with sepsis, correlating with poor clinical outcomes and increased mortality risk.

  • 2

    The study identified 203 differential metabolites in plasma, revealing a distinct metabolic profile in sarcopenic patients.

  • 3

    Key metabolic pathways affected include branched-chain amino acid degradation and steroid hormone synthesis, both downregulated in sarcopenic patients.

  • 4

    Metabolic pathways associated with inflammation and injury were upregulated, indicating a shift towards catabolism in sarcopenic patients.

  • 5

    Findings suggest potential diagnostic biomarkers and therapeutic targets for managing sarcopenia in elderly patients with sepsis.

Original Source(s)

Metabolomic biomarker differences of sarcopenia in older patients with sepsis

  • by Yiyang Liu, Tianren He, Siyu Chen, Ziyi Li, Xue Mei, Xinhua He, Na Shang

  • April 30, 2026

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