Somatic DICER1-Mutant Benign Thyroid Nodules in Adults: A Group of Follicular Nodular Disease With Continuous Growth - Takeaways - MDSpire

Somatic DICER1-Mutant Benign Thyroid Nodules in Adults: A Group of Follicular Nodular Disease With Continuous Growth

  • By

  • Lingyang Meng

  • Haorong Li

  • Yi’an Fu

  • Danyan Yu

  • Jiamin Tang

  • Yan Hu

  • Xiaochun Fei

  • Kaiyu Yang

  • Ziyuan Liu

  • Rongguang Peng

  • Yulin Zhou

  • Shu Wang

  • Jiqi Yan

  • Liyun Shen

  • Rulai Han

  • Lei Ye

  • October 28, 2024

  • 0 min

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  • 1

    Somatic DICER1 mutations were identified in 13 benign thyroid nodules from a cohort of 931 adult-onset thyroid nodules.

  • 2

    DICER1-mutant nodules exhibited significant growth, with 38.5% showing substantial enlargement over time.

  • 3

    All DICER1-mutant nodules were classified as thyroid follicular nodular disease, growing faster than wild-type nodules.

  • 4

    Transcriptomic analysis revealed downregulation of genes related to follicular polarity in DICER1-mutant nodules.

  • 5

    DICER1 2-hit mutations represent a notable percentage of adult patients with thyroid follicular nodular disease.

Original Source(s)

Somatic DICER1-Mutant Benign Thyroid Nodules in Adults: A Group of Follicular Nodular Disease With Continuous Growth

  • by Lingyang Meng, Haorong Li, Yi’an Fu, Danyan Yu, Jiamin Tang, Yan Hu, Xiaochun Fei, Kaiyu Yang, Ziyuan Liu, Rongguang Peng, Yulin Zhou, Shu Wang, Jiqi Yan, Liyun Shen, Rulai Han, Lei Ye

  • October 28, 2024

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