Physical activity as a molecular modulator to enhance immunotherapy and drug sensitivity in the endometrial cancer–comorbidity continuum - Takeaways - MDSpire

Physical activity as a molecular modulator to enhance immunotherapy and drug sensitivity in the endometrial cancer–comorbidity continuum

  • By

  • Jing Wang

  • Zhenyu Yang

  • Yang Wu

  • Menghao Tang

  • Yihan Wang

  • Hongyun Zheng

  • Xinming Ye

  • Mei Du

  • July 7, 2026

  • 0 min

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  • 1

    Endometrial cancer treatment faces challenges from therapeutic resistance, immunosuppressive tumor microenvironments, and patient comorbidities.

  • 2

    Physical activity is proposed as a systems-level molecular modulator that can enhance drug sensitivity and immunotherapy efficacy in endometrial cancer.

  • 3

    Exercise remodels the tumor microenvironment by repolarizing tumor-associated macrophages and enhancing cytotoxic T cell infiltration.

  • 4

    Physical activity improves renal perfusion and normalizes tumor vasculature, which enhances drug delivery and mitigates nephrotoxicity.

  • 5

    The review emphasizes the need for personalized exercise prescriptions to optimize molecular responses in endometrial cancer patients with comorbidities.

Original Source(s)

Physical activity as a molecular modulator to enhance immunotherapy and drug sensitivity in the endometrial cancer–comorbidity continuum

  • by Jing Wang, Zhenyu Yang, Yang Wu, Menghao Tang, Yihan Wang, Hongyun Zheng, Xinming Ye, Mei Du

  • July 7, 2026

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